منابع مشابه
NADPH oxidases of the brain: distribution, regulation, and function.
The NADPH oxidase is a multi-subunit enzyme that catalyzes the reduction of molecular oxygen to form superoxide (O(2)(-)). While classically linked to the respiratory burst in neutrophils, recent evidence now shows that O(2)(-) (and associated reactive oxygen species, ROS) generated by NADPH oxidase in nonphagocytic cells serves myriad functions in health and disease. An entire new family of NA...
متن کاملNOX Family NADPH Oxidases
Proton channels allow cells to extrude excess acid with a high efficiency and therefore are one of the important homeostatic mechanisms that maintain the intracellular pH in a range compatible with life. Proton currents are highly expressed in phagocytes where they are thought to contribute to charge and pH compensation during NADPH oxidase activation. By analogy with the cytochrome C oxidase o...
متن کاملVascular functions of NADPH oxidases.
NADPH oxidases belong to a group of enzymes that generate reactive oxygen species (ROS) by electron transfer from NADPH to molecular oxygen. The product of this reaction is the superoxide anion (O2 ), which undergoes secondary reactions. O2 inactivates NO to yield peroxynitrite and spontaneously or under catalysis of superoxide dismutases reacts to hydrogen peroxide. NADPH oxidases, therefore, ...
متن کاملNADPH Oxidases in Innate Immunity
and Duox in the respiratory epithelium. The location of these ROS-generating enzymes in the barrier tissues has prompted the expectation of their participation in host defense against invading pathogens in these tissues. Indeed, recent studies have begun to support this expectation, demonstrating roles in bacterial killing, cytokine production, apoptosis, gene expression and signaling, includin...
متن کاملNADPH Oxidases in Innate Immunity
and Duox in the respiratory epithelium. The location of these ROS-generating enzymes in the barrier tissues has prompted the expectation of their participation in host defense against invading pathogens in these tissues. Indeed, recent studies have begun to support this expectation, demonstrating roles in bacterial killing, cytokine production, apoptosis, gene expression and signaling, includin...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2006
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000204727.46710.5e